Focally amplified lnc RNA genes in cancer
نویسندگان
چکیده
منابع مشابه
Focally amplified lnc RNA genes in cancer
Genomic instability could lead to the aberration of genes and partially be the cause of carcinogenesis. Researches of cancer drivers are mainly focused on protein-coding genes, especially those are harbored in the genomic regions with high frequent somatic copy-number alterations (SCNAs) in cancer. The protein-coding sequences only took up less than 2% of the whole human genome, although, nearl...
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All proteins are translated from RNA, but only a fraction of RNAs seem to be translated into proteins. Advanced genomics technologies have uncovered noncoding regulatory RNAs exhibiting extraordinary diversity in size, structure, and molecular function. We know a great deal about small (≈20 nucleotides) microRNAs that post-transcriptionally regulate translation of protein from target mRNAs havi...
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Gastric cancer (GC), one of the most common cancers worldwide, has a high mortality rate due to limited treatment options. Identifying novel and promising molecular targets is a major challenge that must be overcome if treatment of advanced GC is to be successful. Here, we used comparative genomic hybridization and gene expression microarrays to examine genome-wide DNA copy number alterations (...
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Recent functional genomic studies revealed that the oncogenic activity of focally amplified lncRNA on chromosome 1 (FAL1, ENSG00000228126) contributes to tumor growth by p21 repression in human cancers. However, the expression of FAL1 was not investigated in papillary thyroid cancer (PTC). We aimed to determine if FAL1 was up-regulated in PTC compared to paired contralateral normal thyroid tiss...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2015
ISSN: 2331-4737
DOI: 10.18632/oncoscience.127